Cissus quadrangularis is a medicinal plant found in the grape family and used to combat a host of ailments, from stomach ulcers to joint pain. Impressively, its ability to promote insulin sensitivity makes it helpful for people with diabetes and metabolic syndrome by addressing the root cause, which is insulin resistance. By lowering insulin resistance, it improves carbohydrate metabolism and helps lower blood glucose levels. Cissus quadrangularis can also be used as a weight loss supplement, according to studies on overweight and obese individuals who were able to lose weight and reduce waist size without changes in diet or exercise habits.